Several months after a probe returning from Mars burns up during reentry, strange creatures dubbed "Ancients" begin to appear throughout Tokyo, wreaking havoc and defying conventional weaponry with their aggressive and resilient nature. As scientists scramble to uncover the cause of their sudden emergence, the monsters continue to wreak havoc globally, prompting humanity to find solace in the development of the MARS suit, a revolutionary weapon designed to counter the Ancients. However, the suit's operational capabilities are limited to individuals possessing specific DNA, making Takeru Hinata, a troubled teenager with a complex past, one of the select few capable of piloting this potent weapon. With the support of the AAST, a specialized police force established to combat the Ancient threat, Takeru embarks on a perilous journey to battle both the monstrous invaders and his personal demons, while unraveling the enigmatic origins of the Earth's newfound aggressors.